AUS1 — Aspergillus fumigatus

Summary

AFU6G04360, symbol AUS1 and also known as atrF, encodes an ABC transporter with ATP hydrolase and ATP-binding activities. In Aspergillus fumigatus, this gene is associated with steroidogenesis, ergosterol anabolism, mating, carbohydrate metabolism, hypersensitivity, and cell growth, and its product localises to the plasma membrane. The gene is linked to numerous phenotypes including abnormal small molecule transport, increased sporulation rate, decreased cell death rate, altered vacuolar distribution and transport, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, and shmoo formation, bipolar budding, and cell cycle progression. Studies of related genes in other species connect the family to traits such as plant height, root length, drought tolerance, and oxidative stress response.