CNB1 — Aspergillus fumigatus

Summary

AFU6G04540 (CNB1, cnaB) on chromosome 6 of Aspergillus fumigatus encodes a protein with EF-hand calcium-binding domains and is annotated with calcium ion binding, phosphatase binding, phosphatase activator activity, calcium-dependent protein serine/threonine phosphatase regulator activity, and calcium-dependent protein serine/threonine phosphatase activity. CNB1 is associated with calcineurin-mediated signaling, calcium ion homeostasis, regulation of phosphorylation and cell morphogenesis, fungal-type cell wall organization, cellular thermotolerance, ER stress response, immune response, interaction with host, and dephosphorylation. It localizes to the calcineurin complex, cytoplasm, cytosol, nucleus, and cell division site. The gene is linked to calcium sensitivity and numerous phenotypes including abnormal cell cycle progression, filamentous growth, bipolar budding, shmoo formation, cell fusion, endocytosis, nuclear export, hyperosmotic stress resistance, and replicative lifespan. Studies of related genes in other species connect the family to loss of pathogenicity and reduced virulence.