ENO1 — Aspergillus fumigatus

Summary

AFU6G06770 (ENO1, AfENO1) encodes an enolase with phosphopyruvate hydratase activity (EC 4.2.1.11), a magnesium-binding enzyme of the glycolytic process. It is annotated to IgE binding, B cell activation, immune evasion, secretion, and cellular responses to farnesol and osmotic stress. The protein localises to the enolase complex. Phenotypic associations link this gene to abnormal filamentous growth, colony color and size, increased cell death and adhesion, absent endocytosis and pexophagy, altered fermentative and respiratory metabolism, defective cytokinesis, spindle morphology, nuclear transport, prion inheritance, and increased critical cell size at the G1 checkpoint. Studies of related genes in other species connect it to additional cellular processes including cell cycle regulation, mitochondrial genome maintenance, and stress resistance.