gliZ — Aspergillus fumigatus

Summary

AFU6G09630 (symbol gliZ) on Aspergillus fumigatus chromosome 6 encodes a Zn₂Cys₆ fungal-type DNA-binding domain transcription factor with sequence-specific DNA-binding and RNA polymerase II-specific transcription factor activity, localised to the nucleus. The gene is associated with the anabolism of gliotoxin and pseurotin A, secondary metabolism, mycotoxin biosynthesis, mycose catabolism, sulfur metabolism, morphogenesis, secretion, phagocytosis, hypersensitivity, cell death, methylation, and positive regulation of transcription. It is also linked to fungal infection in humans and mice, and to zinc concentration. Studies of related genes in other species connect the family to blackleg disease in Brassica napus.