atrR — Aspergillus fumigatus

Summary

AFU6G10140 (atrR) on chromosome 6 of Aspergillus fumigatus encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain and DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, and negative regulation of cellular response to drug. It is linked to siderophore anabolism, reductive iron assimilation, ergosterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, and cellular response to oxidative stress. Localisation evidence links the product to the nucleus, nuclear inner membrane, membrane, and cytosol. Studies of related genes in other species link the family to reduced virulence and pulmonary aspergillosis.