CDA — Aspergillus fumigatus

Summary

AFU6G10430, symbol CDA, on Aspergillus fumigatus chromosome 6, encodes a putative chitin deacetylase with chitin deacetylase activity (EC 3.5.1.41), chitin binding, zinc and metal binding, and hydrolase activity. It contains a NODB domain, a chitin-binding type-1 domain, and an endochitinase-like superfamily domain. The gene is associated with chitin breakdown, chitosamine metabolism, polysaccharide breakdown, carbohydrate metabolism, fungal-type cell wall biogenesis, cell wall organization, and immune evasion. Its product localizes to the fungal-type cell wall, plasma membrane, extracellular region, and side of membrane. Studies of related genes in other species link the family to reduced virulence and turgor pressure, and the gene is also associated with LCP1.