GAS1 — Aspergillus fumigatus

Summary

AFU6G12410 (GAS1, also known as gel7) encodes a glucanosyltransferase with 1,3-beta-glucanosyltransferase activity, belonging to the glycoside hydrolase superfamily and containing an X8 domain. This gene is associated with fungal-type cell wall assembly and biogenesis, cell wall polysaccharide anabolism, glycan biosynthesis, and nucleotide-sugar metabolism. It is linked to host invasion, development of symbiont in host, adhesion of symbiont to host, single-species biofilm formation in or on host organism, cell-substrate adhesion, cellular response to pH and calcium ions, division septum assembly, and establishment or maintenance of cell polarity. The protein localizes to sites of polarized growth, including new and old growing cell tips, cell septum edging, primary cell septum, cellular bud membrane and scar, external side of plasma membrane, vesicles, and lipid rafts. Studies of related genes in other species link the family to reduced virulence.