PMC1 — Aspergillus fumigatus

Summary

AFU7G01030 (symbol PMC1, also known as pmcC) encodes a P-type ATPase of the IIB subfamily, annotated with P-type potassium:proton transporter activity, K+-transporting ATPase activity, and calcium ion binding. The gene is associated with potassium ion export from the cell, sodium transport, calcium transport, cell pH regulation, and manganese ion membrane transport. It has been linked to vacuolar, Golgi, and ER membrane localisation, as well as the plasma membrane and cell tip. Phenotypic associations include abnormal Golgi distribution, absent spore germination, decreased necrotic cell death, increased ionic stress resistance, and altered vacuolar transport. Related genes in other species link the family to calcium sensitivity and reduced virulence.