cyp51B — Aspergillus fumigatus

Summary

AFU7G03740 (cyp51B) on chromosome 7 of Aspergillus fumigatus encodes a cytochrome P450 family protein with sterol 14-demethylase activity (EC 1.14.14.154), also annotated for methyltransferase activity, iron and heme binding, and redox activity. The gene is associated with ergosterol and sterol anabolism, demethylation, methylation, D-amino acid metabolism, glutathione metabolism, nucleotide metabolism, homologous recombination, mismatch repair, autophagy, and response to stress. The encoded product localises to the membrane. The gene is associated with a lethal pathogen phenotype and invasive pulmonary aspergillosis, with evidence from Mus musculus. Related genes in other species are linked to reduced virulence and associations with Fusarium head blight in wheat.