Arp1 — Aspergillus fumigatus

Summary

AFU7G06800 (symbol Arp1) in Aspergillus fumigatus chromosome 7 encodes a glutamyl-tRNA(Gln) amidotransferase subunit A, a protein with an amidase domain and asparagine synthase family domain. It is associated with urea carboxylase, allophanate hydrolase, and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activities, and binds ATP and metal ions. It is associated with DHN-melanin biosynthesis, pigmentation, melanin anabolism, sporulation, L-phenylalanine breakdown, urea breakdown, immune evasion, and mitochondrial translation. The protein localizes to the glutamyl-tRNA(Gln) amidotransferase complex and mitochondria. Studies of related genes in other species link the family to allophanate hydrolase (EC 3.5.1.54) and urea carboxylase (EC 6.3.4.6) activities, as well as to the DUR1,2 urea amidolyase system.