CLM2 — Aspergillus fumigatus

Summary

AFU8G00740 (symbol CLM2, preferred name AfCLM2) on chromosome 8 of Aspergillus fumigatus encodes a cytochrome P450 with progesterone monooxygenase activity, heme and iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with sterol homeostasis, demethylation, fatty acid oxidation, asexual reproduction and sporulation, mitochondrial fission, actin depolymerization, prenylation, protein farnesylation, glutathione metabolism, inflammatory response, phagocytosis, and DNA amplification. It is linked to abnormal plasma membrane and endoplasmic reticulum morphology, altered cell shape and size, decreased vegetative and invasive growth, increased cell death and apoptosis, increased biofilm formation, decreased alkaline pH and hydrostatic pressure resistance, and altered carbon and iron source utilization. Related genes in other species link the family to toxin resistance.