CLM2 — Aspergillus fumigatus

Summary

AFU8G00760 (symbol CLM2, also known as AfCYP51A and AfERG11) on chromosome 8 of Aspergillus fumigatus encodes a cytochrome P450 monooxygenase with heme and iron binding, acting on paired donors with oxygen incorporation. This gene is associated with sterol homeostasis, demethylation, asexual reproduction and sporulation, fatty acid oxidation, protein farnesylation, and mitochondrial fission. It is linked to the ER membrane and broader membrane localisation. Phenotypic associations include decreased vegetative and invasive growth, increased cell death, abnormal cell cycle progression, decreased nutrient uptake and iron utilization, and hyperosmotic stress and ionizing radiation. The gene is also connected to micronucleophagy, ribophagy, and endoplasmic reticulum distribution. Related genes in other species link the family to ergosterol biosynthesis.