AUS1 — Aspergillus fumigatus

Summary

AFU8G02650 (AUS1) encodes a putative ABC multidrug transporter of the ABCG/PDR family, with ATP hydrolase activity and ATP binding. It is localized to the plasma membrane and membrane. The gene is associated with steroidogenesis, ergosterol anabolism, mating, carbohydrate metabolism, hypersensitivity, and cell growth. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, and altered nutrient uptake, vacuolar distribution, endocytosis, mitophagy, and cell cycle progression. Studies of related genes in other species link the family to traits such as plant height, root length, drought tolerance, and oxidative stress response.