SKS2 — Aspergillus fumigatus

Summary

AFU8G03930 (SKS2, also known as hscA, HSP70-2, SSB2, or SSB1) on Aspergillus fumigatus chromosome 8 encodes a member of the Hsp70 family of molecular chaperones, possessing ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions, and is annotated as a NES receptor. The gene is associated with protein refolding, multidomain protein assembly, the ER stress response, exocytosis, nuclear export, translation, and ribosome biogenesis. It localizes to the cytoplasm, cytosol, nucleus, plasmalemma, and fungal biofilm matrix. Phenotypic associations include increased thermotolerance, abnormal spore germination, premature apoptosis, altered cell cycle progression (including G1/S and G2/M transitions), and changes in protein transport and accumulation. Sequence similarity links the family to loss of pathogenicity in other fungi and to protein content traits.