OGM4 — Aspergillus fumigatus

Summary

AFU8G04500 (OGM4/PMT4) in Aspergillus fumigatus encodes a protein with protein O-mannosyltransferase activity (EC 2.4.1.109). The gene is associated with protein O-linked glycosylation, fungal-type cell wall organization, hyphal growth, filamentous growth, conidia formation, biofilm formation on inanimate substrates, cell-substrate adhesion, and interaction with the host. It is also linked to the regulation of ER unfolded protein response, downregulation of proteolysis, and cellular responses to neutral pH, starvation, and xenobiotic stimuli. The product localizes to the ER membrane, nuclear membrane, endomembrane system, and plasmalemma. Studies of related genes in other species link the family to virulence and mannose content.