VELB — Aspergillus fumigatus

Summary

AFU1G01970 (symbol VELB, preferred name AfVELB) on chromosome 1 of Aspergillus fumigatus encodes a velvet complex subunit B, a member of the Velvet domain-containing protein family. This gene is associated with negative regulation of conidiophore development and conidium formation, positive and negative regulation of sexual sporulation, cellular responses to light stimulus, UV, and hydrogen peroxide, spore wall assembly, spore germination, mycose biosynthesis, sterigmatocystin and aflatoxin biosynthetic processes, the TCA cycle, and cellular localization. The encoded protein localizes to both the cytoplasm and nucleus. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.