PMA1 — Aspergillus fumigatus

Summary

AFU1G02480 (AfPMA1) encodes a P-type ATPase of the IIIA subfamily, a proton-transporting ATPase (EC 7.1.2.1) with proton-binding, ATP-binding and ATP hydrolase activities, and is also annotated with manganese and calcium transporter activities. In Aspergillus fumigatus, AfPMA1 is associated with proton export across the plasma membrane, cell pH regulation, manganese and calcium ion transport and homeostasis, and macroautophagy. It localises to the plasma membrane, Golgi, ER, nuclear envelope, lipid rafts, extracellular vesicles, and cell tips and division sites. Phenotypic associations link AfPMA1 to abnormal spore germination, delayed sporulation, altered cell death rate, impaired hyperosmotic stress resistance, aberrant plasma membrane morphology, and defects in protein transport, endocytosis, autophagy (mitophagy, pexophagy, micronucleophagy), and cell cycle progression through G2/M. Related genes in other species connect the family to loss of pathogenicity and reduced virulence.