DIS2 — Aspergillus fumigatus

Summary

AFU1G04950 (DIS2, also known as glcA) on chromosome 1 encodes a serine/threonine-protein phosphatase with protein phosphatase activity and RNA polymerase II C-terminal domain T4 phosphatase activity, belonging to the PP1 catalytic subunit family. This gene is associated with the regulation of glycogen and glycerol anabolism, cell cycle modulation including mitotic entry and exit, cytokinesis, cell polarization, anisotropic cell growth, clathrin-mediated endocytosis, and centromere clustering. It is linked to the PTW/PP1 phosphatase complex and localizes to the bud neck septin collar, cell cortex, and kinetochore. Phenotypic associations include abnormal spore wall formation, bipolar budding, cell cycle progression, chromosome segregation, alkaline pH resistance, desiccation resistance, and filamentous growth. Related genes in other species connect it to similar cell cycle and metabolic processes.