FLO8 — Aspergillus fumigatus

Summary

AFU1G06060 (FLO8, also known as MSS11, IXR1, or MED15) in Aspergillus fumigatus encodes a Mediator complex subunit 15 KIX domain-containing protein that is a transcriptional co-regulator. This gene is associated with flocculation, biofilm formation, pseudohyphal growth, filamentous growth, spore formation, autophagy, and homeostasis, as well as regulation of transcription by RNA polymerase II. It localizes to the Mediator complex. The gene is linked to invasive pulmonary aspergillosis and has been studied in Galleria mellonella. Associations include oxidative stress response and numerous cell cycle phenotypes, such as altered G1/S and G2/M phase progression, increased resistance to gamma rays, X-rays, UV, and acid pH, as well as changes in cell size, budding pattern, mating response, and vegetative growth rate.