ptcB — Aspergillus fumigatus

Summary

AFU1G09280 (ptcB) on Aspergillus fumigatus chromosome 1 encodes a protein with PP2C_BS and PPM-type phosphatase domains, exhibiting MAP kinase serine/threonine phosphatase activity, adenylyl cyclase activity, protein serine/threonine phosphatase activity, and metal binding. The gene is associated with downregulation of MAPK and p38 cascades, cAMP anabolism, the endoplasmic reticulum unfolded protein response, cellular osmotic response, intracellular signal transduction, biofilm formation, and fungal-type cell wall organization. Its product localizes to the cytoplasm, cytosol, and nucleus. Related genes in other species link the family to germination rate, oxidative stress response, and phosphorus concentration. The gene has also been connected to invasive pulmonary aspergillosis in a mouse model.