AMT1 — Aspergillus fumigatus

Summary

AFU1G10930 (AMT1) of Aspergillus fumigatus encodes a protein with ammonium transporter and ammonia channel domains, and has methylammonium transmembrane transporter activity and ammonium channel activity. The gene is associated with ammonium import across the plasma membrane, ammonium membrane transport, and methylammonium membrane transport. It is also associated with host invasion, proteolysis, and localization to the plasma membrane, fungal-type vacuole, and Golgi complex. Phenotypic associations include abnormal biofilm formation, increased virulence, increased sporulation, decreased nitrogen source utilization, abnormal filamentous growth, altered cell cycle progression, increased necrotic cell death, and abnormal autophagy and pexophagy. Related genes in other species link the family to protein content.