CLM2 — Aspergillus fumigatus

Summary

AFU1G11390 (CLM2, AfCLM2) on chromosome 1 of Aspergillus fumigatus encodes a putative cytochrome P450 with monooxygenase activity, heme and iron binding, and EC 1.14.99.9 (an oxidoreductase acting on paired donors). The gene is associated with sterol homeostasis, demethylation, asexual reproduction and sporulation, fatty acid oxidation, mitochondrial fission, and membrane localisation. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; abnormal cell cycle progression through G2/M and S phases; increased cell death; arrested vegetative and exponential-phase growth; decreased invasive growth, nutrient uptake, and utilization of iron and phosphorus sources; and increased lifespan. The gene is also linked to hyperosmotic stress resistance, ionizing radiation resistance, and abnormal plasma membrane morphology. Related genes in other species include ERG24, ERG9, and ERG28.