GANB — Aspergillus fumigatus

Summary

AFU1G12930, symbol GANB (also known as gpaB, GNA-3), encodes the G protein complex alpha subunit GpaB in Aspergillus fumigatus on chromosome 1. This product possesses GTPase activity, binds GTP and metal ions, and has adenylate cyclase activator activity, G protein-coupled receptor binding, and G-protein beta/gamma-subunit complex binding. The gene is associated with the cAMP/PKA signaling cassette, GPCR signaling pathways, glucose-sensing PKA pathway, adenylate cyclase-activating GPCR signaling pathway, asexual sporulation, spore germination, invasive growth in response to glucose limitation, developmental process, glucose mediated signalling, pheromone response, ascospore formation, conidia formation, biofilm formation, secondary metabolism, pseudohyphal growth, and sporulation. It localizes to the heterotrimeric G-protein complex and cytoplasm. GANB is linked to aspergillosis and has been connected to germination rate. Studies of related genes in other species associate the family with loss of pathogenicity and various plant diseases including smut, southern corn leaf blight, and grey mold.