TRP1 — Aspergillus fumigatus

Summary

AFU1G13090 (AfTRP1) on chromosome 1 of Aspergillus fumigatus encodes a multifunctional enzyme with anthranilate synthase, phosphoribosylanthranilate isomerase, and indole-3-glycerol-phosphate synthase activities (EC 4.1.3.27, 5.3.1.24, 4.1.1.48). The gene is associated with tryptophan formation and the shikimate pathway, and its product localises to the cytosol as part of the anthranilate synthase complex. AfTRP1 has been linked to numerous phenotypes including decreased filamentous growth, sporulation, and invasive growth, as well as altered stress responses such as increased thermotolerance and decreased resistance to UV, gamma rays, and hyperosmotic stress. Associations also include increased chronological lifespan, abnormal cell cycle progression, reduced autophagy, and altered carbon source utilisation and fermentative growth. Studies of related genes in other species connect the family to oxidative stress response and nitrogen source utilisation.