mac1 — Aspergillus fumigatus

Summary

AFU1G13190 (symbol mac1) on chromosome 1 of Aspergillus fumigatus encodes a copper-fist DNA-binding domain-containing transcription factor that binds copper and zinc, localises to the nucleus, and regulates RNA polymerase II-dependent transcription. The gene is associated with cellular copper and iron ion homeostasis, the response to copper, and conidiophore development. It has also been linked to invasive aspergillosis and invasive pulmonary aspergillosis, with studies in Mus musculus connecting the gene family to these disease processes. Studies of related genes in other species further associate the family with fungal pathogenesis.