SOD2 — Aspergillus fumigatus

Summary

AFU1G14550 (SOD2, also known as sod3) encodes a manganese/iron superoxide dismutase (Mn/Fe_SOD family) with superoxide dismutase activity and manganese binding, localised to the mitochondrial lumen, mitochondria and cytosol. The gene is associated with evasion or tolerance of host-produced AOS, removal of O2-, hyphal growth, detoxification, hypersensitivity, autophagy, and processes including D-amino acid, glutathione and nucleotide metabolism, calcium signalling, NO storage, homologous recombination and homeostasis. It is linked to photosynthetic rate and oxidative stress response. Phenotypic associations include altered carbon source utilisation, protein activity, chemical compound accumulation, polyploidy, anaerobic and fermentative growth, necrotic cell death, mating type switching, respiratory metabolism, hydrostatic pressure and freeze-thaw resistance, nucleophagy and ribophagy, cell cycle progression, stationary phase entry, mitochondrial transport, pheromone sensitivity and production, radiation and alkaline pH resistance, spore wall and septum formation, and survival rate in stationary phase. Studies of related superoxide dismutase genes in other species link the family to sodium concentration, manganese content, salt tolerance, phosphate content, acid sensitivity and unaffected pathogenicity.