sidC — Aspergillus fumigatus

Summary

AFU1G17200 (symbol sidC) on chromosome 1 of Aspergillus fumigatus encodes a protein with ligase activity and phosphopantetheine binding, belonging to the AMP-binding and ACP-like superfamilies. The gene is associated with siderophore biosynthesis, including ferrichrome, ferricrocin, and gliotoxin anabolism, as well as nonribosomal peptide anabolism, reductive iron assimilation, cellular response to iron ion starvation, and iron homeostasis. It is also linked to asexual sporulation, germ tube formation, secondary metabolism, and nitric oxide storage. The product localizes to the cytoplasm. Studies of related genes in other species link the family to altered virulence, including hypervirulence and reduced virulence, and to associations with plant pathogens such as Fusarium oxysporum and Zea mays (causal agent of southern corn leaf blight).