hmgR — Aspergillus fumigatus

Summary

AFU2G00100 (symbol hmgR) in Aspergillus fumigatus chromosome 2 encodes a C6 transcription factor Aro80, putative, belonging to the Zn2Cys6 DNA-binding domain family. The product possesses DNA-binding transcription factor activity specific to RNA polymerase II and is localized to the nucleus. This gene is associated with the breakdown of aromatic amino acids, including tyrosine and L-phenylalanine, and with positive regulation of transcription by RNA polymerase II. Studies of related genes in other species link the family to catabolic regulation, though this is not established for hmgR itself.