srcA — Aspergillus fumigatus

Summary

AFU293_100821 (srcA) on Aspergillus fumigatus chromosome 5 encodes a putative H/K ATPase alpha subunit, a P-type cation-transporting ATPase with sodium/potassium-exchanging, potassium:proton-transporting, and K+-transporting ATPase activity (EC 3.6.3.10). The gene is associated with potassium ion import across the plasma membrane, potassium ion export, sodium transport, calcium transport, manganese ion membrane transport, and proton export across the plasma membrane. It is linked to cellular ion homeostasis for potassium, sodium, and manganese, as well as cell pH regulation and reduction. Localisation evidence connects srcA to the plasma membrane, lipid raft, Golgi membrane, ER membrane, fungal-type vacuole membrane, and extracellular vesicles. Studies of related genes in other species link the family to reduced virulence and loss of pathogenicity, and to pulmonary aspergillosis.