LEU3 — Aspergillus fumigatus

Summary

AFU1G15000 (AfLEU3) encodes a 2-isopropylmalate synthase (EC 2.3.3.13). The protein localises to mitochondria and contains conserved LeuA and aldolase-type TIM barrel domains. In Aspergillus fumigatus, the gene is associated with L-leucine and valine anabolism, siderophore metabolism, proteolysis, autophagy, and homeostasis. Phenotypic associations link AfLEU3 to cell cycle progression, budding pattern, pseudohyphal growth, fermentative metabolism, acid pH and osmotic stress resistance, acquired thermotolerance, prion dynamics, and nuclear export. Studies of related genes in other species connect the family to reduced virulence and loss of pathogenicity, and the gene has been linked to pulmonary aspergillosis in animal models.