ARP2 — Aspergillus fumigatus

Summary

AFU1G13330 (AfARP2) on chromosome 1 encodes the Arp2/3 complex subunit Arp2, a putative structural constituent of the cytoskeleton with ATP hydrolase activity and F-actin binding. The gene is associated with actin filament branching, cortical patch organization and assembly, endocytosis, phagocytosis, mitochondrial migration and inheritance, DHN-melanin biosynthesis and pigmentation, ascospore wall assembly, DNA repair-dependent chromatin remodeling, and regulation of transcription. Localization evidence links the product to the actin cytoskeleton, actomyosin contractile ring, hyphal tip, perinuclear region, and chromatin-remodeling complexes including Ino80, TIP60, and SWR-C. Phenotypic associations include abnormal filamentous growth, decreased cytokinesis and endocytosis rates, absent cell cycle progression, altered budding patterns, and absent innate thermotolerance. Studies of related genes in other species connect the family to delayed cytokinesis and abnormal chitin deposition.