AUS1 — Aspergillus fumigatus

Summary

AFU1G14330 (symbol AUS1, also known as abcC) encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase and ATP-binding activities. In Aspergillus fumigatus, this plasma-membrane protein is associated with steroidogenesis, ergosterol anabolism, xenobiotic detoxification via transmembrane export, calcium signaling, hyphal growth, mating, spore formation, carbohydrate metabolism, cell growth, and hypersensitivity. The gene has been linked to invasive pulmonary aspergillosis in mouse and Galleria mellonella models. Annotated phenotypes include abnormal small-molecule transport, increased sporulation rate, decreased cell death, delayed mitophagy, and altered cell cycle progression.