CAG1 — Aspergillus fumigatus

Summary

AFU1G13140 (CAG1, gpaA) in Aspergillus fumigatus encodes a G-protein complex alpha subunit (GpaA/FadA) with GTPase activity and guanyl nucleotide binding. This gene is associated with GPCR signaling, regulation of conidium formation, asexual sporulation, spore germination, developmental induction, autolysis, protein secretion, and secondary metabolism including sterigmatocystin and melanin biosynthesis. It localizes to the heterotrimeric G-protein complex, cytoplasm, and mitochondrial outer membrane. The gene is linked to germination rate and numerous phenotypes including altered mating efficiency, pheromone production, cell cycle progression, sporulation timing, and nuclear fusion during mating. Related genes in other species have been linked to virulence and pathogenicity.