SSD1 — Aspergillus fumigatus

Summary

AFU1G11420 (SSD1, AfSSD1) on Aspergillus fumigatus chromosome 1 encodes a putative cell wall biogenesis protein phosphatase Ssd1 with RNA exonuclease activity, 3'-5' exoribonuclease activity, and mRNA 5'-UTR binding activity. The gene is associated with RNA surveillance, rRNA processing and breakdown, nuclear mRNA catabolic processes, termination of RNA polymerase II transcription, and intracellular mRNA localization. It is associated with cell cycle progression, particularly the G1/S phase transition, as well as polyploidy, budding, protein transport, and hypoosmotic stress resistance. Additional associations include alkaline pH resistance, fermentative and respiratory metabolism, mitochondrial transport, peroxisomal distribution, and mating type switching. Studies of related genes in other species link the family to virulence, flocculation, and protein content.