CAP1 — Aspergillus fumigatus

Summary

AFU1G12760 (CAP1, capA) on Aspergillus fumigatus chromosome 1 encodes an adenylyl cyclase-associated protein. The product binds adenylyl cyclase and actin, and is linked to identical protein binding. It is associated with actin filament destabilization and severing, actin depolymerization, regulation of actin polymerization, and actin filament organization. The protein localizes to the growing cell tip, cross wall, actin patch, division septum, and cytoplasm. CAP1 is associated with Ras protein signal transduction, upregulation of Ras signaling, positive regulation of mitochondrial fission, downregulation of cell growth, the glucose-sensing PKA pathway, and secondary metabolite biosynthesis. Phenotypic associations include abnormal filamentous growth, absent spore germination, sterility, abnormal endocytosis, chitin deposition, autophagy, cell cycle progression, and increased pexophagy. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.