NIAD — Aspergillus fumigatus

Summary

AFU1G12830 (NIAD, niaD) in Aspergillus fumigatus encodes a nitrate reductase, an enzyme with nitrate reductase (NADPH) activity (EC 1.7.1.3) that also exhibits sulfite oxidase, cytochrome-b5 reductase, NADH dehydrogenase, and transferase activities, and binds FAD, heme, molybdenum, and Moco. The gene is associated with nitrate assimilation, anaerobic respiration, cellular respiration, detoxification, and the biosynthesis of nitric oxide, gliotoxin, ergosterol, siderophores, and thiamin. It is also linked to polysaccharide and sulfur metabolism, arginine metabolism, metal ion transport, regeneration, and the mitotic cell cycle. The encoded protein localizes to the mitochondrial outer membrane, endoplasmic reticulum, and plasma membrane. Studies of related genes in other species connect the family to nitrate transport and uptake, as well as molybdenum content.