FOX3 — Aspergillus fumigatus

Summary

AFU1G12650 (FOX3, also known as kat1) in Aspergillus fumigatus encodes a thiolase-domain protein with acetyl-CoA C-acetyltransferase (3-ketothiolase) activity and metal binding. The gene is associated with fatty acid beta-oxidation, eoxin synthesis, arachidonic acid metabolism, prostaglandin anabolism, phenylacetate breakdown, and ergosterol anabolism. Its product localises to peroxisomes, mitochondria, and the cytosol. FOX3 is associated with absent peroxisomal transport and morphology, abnormal peroxisomal distribution and morphology, decreased peroxisomal transport, arrested vegetative growth, abnormal vegetative growth, abnormal sporulation, increased mutation frequency, decreased biofilm formation, absent and decreased carbon source utilisation, decreased anaerobic and respiratory growth, decreased acid pH resistance, increased and decreased replicative lifespan, increased and decreased stress resistance, increased invasive growth, and decreased desiccation resistance. Related genes in other species link the family to peroxisomal function and PTS2-mediated protein import.