HMG1 — Aspergillus fumigatus

Summary

AFU1G11230 (HMG1, also known as HMG2) in Aspergillus fumigatus encodes a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34). The protein localises to the endoplasmic reticulum and is associated with isoprenoid, sterol, ergosterol and siderophore (N',N'',N'''-triacetylfusarinine C) biosynthesis, as well as with CoA metabolism, biofilm formation, sporulation and phagocytosis. The gene has been linked to diverse cellular processes including cell cycle progression, nuclear import, protein secretion, vacuolar transport, mitophagy, ribophagy, nucleophagy, meiosis, telomere length maintenance, oxidative phosphorylation, ionic stress resistance, UV resistance, colony morphology and replicative lifespan. Related genes in other species have been linked to reduced virulence.