PGK — Aspergillus fumigatus

Summary

AFU1G10350 (PGK, pgkA) encodes a phosphoglycerate kinase with phosphoglycerate kinase activity (EC 2.7.2.3), binding ATP, ADP, and metal ions. The gene is associated with glycolytic process, gluconeogenesis, negative regulation of pyruvate decarboxylation to acetyl-CoA, and biofilm formation. The product localizes to both mitochondria and cytosol. Associations with respiration rate and numerous phenotypes have been recorded, including increased cell cycle progression through S phase and G1/S transition, decreased cell death, abnormal replicative lifespan, increased adhesion and mating efficiency, delayed autophagy, decreased necrotic cell death, and abnormal prion inheritance and formation. The gene is also linked to altered vacuolar distribution, bipolar budding pattern, colony color and shape, sterile phenotype, decreased cell fusion, and absence of innate thermotolerance, fermentative growth, and pheromone-induced cell cycle arrest.