FGM5 — Aspergillus fumigatus

Summary

AFU1G10390 (symbol FGM5, also known as abcB) on Aspergillus fumigatus chromosome 1 encodes an ABC transporter with ATP hydrolase activity and ATP binding, belonging to the ABCC subfamily with multiple transmembrane domains. The gene is associated with homologous recombination, sporulation, hyphal growth, and membrane transport, and its product localizes to the fungal-type vacuole membrane, plasmalemma, and general membrane. Studies of related genes in other species link the family to reduced virulence and associations with Fusarium head blight and various plant pathogens including Fusarium oxysporum and Verticillium dahliae, as well as connections to crop species such as barley, maize, and wheat.