PMC1 — Aspergillus fumigatus

Summary

AFU1G10880 (symbol PMC1, also known as pmcA) on chromosome 1 of Aspergillus fumigatus encodes a P-type ATPase of the IIB subfamily with P-type potassium:proton transporter activity, K+-transporting ATPase activity, and additional annotations for sodium, manganese, and calcium transporter activities. The gene is associated with potassium ion export, sodium transport, calcium transport, manganese ion membrane transport, proton export across the plasma membrane, and cellular ion homeostasis. It has been linked to calcium sensitivity and a wide range of phenotypes including abnormal Golgi distribution, absent spore germination, decreased necrotic cell death, increased ionic stress resistance, and altered vacuolar transport. The encoded protein localizes to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. Related genes in other species are linked to calcium-transporting ATPase activity and, in some cases, reduced virulence.