zafA — Aspergillus fumigatus

Summary

AFU1G10080 (symbol zafA) on Aspergillus fumigatus chromosome 1 encodes a putative C2H2 transcription factor with GLI_C2H2-type zinc-finger domains. The protein exhibits DNA-binding transcription activator activity specific to RNA polymerase II, RNA polymerase III general initiation factor activity, 14-3-3 protein binding, and 5S rRNA binding. It is associated with regulation of pseurotin A and gliotoxin anabolism, secondary metabolism, zinc transport and import, cellular zinc ion homeostasis, response to zinc, calcium signaling and cellular calcium ion homeostasis, calcineurin-mediated signaling, response to oxidative stress, phagocytosis, hyphal growth, and 5S rRNA transcription. The gene is linked to aspergillosis and has been studied in Mus musculus. It localizes to the nucleus, cytoplasm, cytosol, chromatin, and transcription regulator complex. Related genes in other species connect the family to calcineurin-mediated signaling and stress responses.