IVN1 — Aspergillus fumigatus

Summary

AFU1G07740, designated IVN1 in Aspergillus fumigatus and located on chromosome 1, encodes a LEM3/CDC50 family protein with aminophospholipid flippase activity and ATP hydrolase activity. The gene is associated with phospholipid translocation and the meiotic cell cycle, and its product localises to the APLT complex, late endosome, Golgi complex, endoplasmic reticulum membrane and plasmalemma. Phenotypic associations include decreased flocculation, reduced spore germination rate, absent fermentative growth, abnormal filamentous and pseudohyphal growth, abnormal chitin deposition, decreased adhesion and meiosis, increased alkaline pH resistance, and altered endocytosis, protein transport, vesicle distribution, vacuolar transport, autophagy and nuclear transport. Related genes in other species link IVN1 to zinc and acid sensitivity and oxidative stress response.