SSA1 — Aspergillus fumigatus

Summary

AFU1G07440 (SSA1) in Aspergillus fumigatus encodes a heat shock 70 kDa protein (Hsp70 family) with ATP hydrolase activity, ATP binding, heat shock protein binding, and protein folding chaperone functions, also annotated as a transcriptional co-regulator. This gene is associated with protein refolding, spore germination, cellular response to heat and farnesol, actin cytoskeleton organization, phagocytosis, immune evasion, interaction with host, and regulation of transcription by RNA polymerase II. It localizes to the cytoplasm, nucleus, extracellular region, fungal-type cell wall, and plasmalemma. Associations include increased thermotolerance, altered cell cycle progression, abnormal spore germination, premature apoptosis, and increased prion inheritance. Related genes in other species link the family to amino acid, protein, and phosphate content, as well as acid sensitivity.