PIN4 — Aspergillus fumigatus

Summary

AFU1G05450 (symbol PIN4, also known as par1) in Aspergillus fumigatus encodes a peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cis-trans proline isomerase activity and DNA binding, belonging to the PPIase_PpiC domain family. The gene is associated with dephosphorylation, hyphal growth, rRNA processing, and cell division, and its product localises to the nucleus. Studies of related genes in other species link the family to increased virulence (hypervirulence) and associations with plant pathogens such as Fusarium oxysporum and Verticillium dahliae, as well as diseases including ear rot in corn and yellow mold in peanut.