CI-1 — Aspergillus fumigatus

Summary

AFU1G03950, also known as CI-1 or erg5, encodes a cytochrome P450 family protein with C-22 sterol desaturase activity, sterol 14-demethylase activity, oxidoreductase activity, iron binding, heme binding, monooxygenase activity, and redox activity. In Aspergillus fumigatus, this gene is associated with ergosterol, sterol, melanin, and terpenoid anabolism, as well as filamentous growth of a population of unicellular organisms in response to starvation, filamentous growth of a population of unicellular organisms in response to biotic stimulus, cellular response to starvation, and hypersensitivity. The encoded protein localizes to the perinuclear ER, cortical ER, ER membrane, ER, plasma membrane, and membrane. Studies of related genes in other species link the family to reduced virulence, potassium concentration, and acid sensitivity. The gene has been associated with numerous phenotypes including altered endocytosis, autophagy, cell cycle progression, cytokinesis, cell death, mitochondrial distribution, vacuolar transport, and vegetative growth arrest.