ERG2 — Aspergillus fumigatus

Summary

AFU1G04720 (ERG2) on chromosome 1 of Aspergillus fumigatus encodes a C-8 sterol isomerase. The gene is associated with sterol and ergosterol anabolism, cellular response to xenobiotic stimulus, and localisation to the endoplasmic reticulum membrane. Associations with numerous cellular processes have been observed, including abnormal autophagy, decreased cell fusion, increased cell death, altered cell cycle progression, and impaired vacuolar transport. The gene is also linked to changes in nutrient uptake, flocculation, cold sensitivity, and starvation resistance. Studies of related genes in other species connect the family to reduced virulence, cell membrane stability, germination rate, and responses to oxidative stress, zinc, and acid.