gliK — Aspergillus fumigatus

Summary

AFU1G02080 (symbol gliK) on Aspergillus fumigatus chromosome 1 encodes a gamma-glutamylcyclotransferase with L-glutamic cyclase activity (EC 4.3.2.9). The gene is associated with gliotoxin anabolism, as well as the regulation and inhibition of gliotoxin anabolism, and with mycotoxin anabolism and homeostasis. The encoded protein is localised to the membrane. Studies of related genes in other species link the gamma-glutamylcyclotransferase family to secondary metabolite biosynthesis pathways.