HAC1 — Aspergillus fumigatus

Summary

AFU8G05230, symbol HAC1 and also known as AfHAC1 or AfPXP1, encodes a 2-hydroxyacyl-CoA lyase in Aspergillus fumigatus chromosome 8. The product belongs to the HACL1-like family and possesses 2-hydroxyacyl-CoA lyase activity (EC 4.1.2.63), along with acetolactate synthase, pyruvate decarboxylase, TPP-binding, magnesium-binding, and FAD/FADH2-binding activities. It is associated with fatty acid alpha-oxidation, valine, isoleucine, and leucine anabolism, protein folding, secretion, and homeostasis. The protein localizes to the peroxisomal lumen, peroxisome, acetolactate synthase complex, fungal biofilm matrix, mitochondria, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity and altered sporulation, respiratory growth, replicative lifespan, and chemical resistance.