RODA — Aspergillus fumigatus

Summary

AFU8G07060 (symbol RODA, also known as rodC) in Aspergillus fumigatus encodes a hydrophobin family protein that is a structural constituent of the cell wall. The gene is associated with asexual spore wall assembly, spore dispersal, conidium and spore germination, and asexual sporulation. It is linked to interactions with the host, including symbiont-mediated suppression of host neutrophil extracellular trap formation, immune evasion, and modulation of cytokine production, inflammatory response, and immune response. Additional associations include MIP2 production, melanin anabolism, phagocytosis, and spore wall and fungal-type cell wall localisation. Studies of related genes in other species link the family to sporogenesis.